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Widespread expression of intestinal markers in gastric carcinoma: a light and electron microscopic study using BD-5 monoclonal antibody.

机译：肠标志物在胃癌中的广泛表达：使用BD-5单克隆抗体的光学和电子显微镜研究。

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BD-5 monoclonal antibody reacted with tumour cells in 262 of 316 cases of gastric cancers, including 121 of 134 early, 141 of 182 advanced tumours (p less than 0.01), and 113 of 146 glandular, 72 of 83 diffuse, 22 of 25 mucoid, and 55 of 59 mixed tumours. No difference in reactivity was observed between metastatic and non-metastatic advanced tumours. Immunocytochemical techniques applied to light and electron microscopical specimens of colorectal mucosa and gastric cancer showed that BD-5 immunoreactive material occurred in the Golgi complex, in small clear, to dense cored, cytoplasmic vesicles, and in the glycocalix of the luminal and lateral membranes of normal and neoplastic cells in the glands, as well as in the peripheral membrane of dispersed neoplastic cells. Mucin granules stored in the cytoplasm of goblet cells were unreactive or poorly reactive. Ultrastructural features consistent with colorectal type differentiation were observed in many reactive tumours. Unreactive tumours showing ultrastructural patterns consistent with intestinal differentiation, especially of small bowel type, were also observed. Signs of intestinal differentiation, including BD-5 immunoreactivity, often occur in gastric cancer, irrespective of histological type and stage of disease.
机译：BD-5单克隆抗体在316例胃癌中的262例中与肿瘤细胞反应，包括134例早期的121例，182例晚期肿瘤的141个（p小于0.01）和146例腺的113例，83例弥漫性的72例，25例中的22例粘液样，以及59种混合肿瘤中的55种。在转移性和非转移性晚期肿瘤之间未观察到反应性的差异。免疫细胞化学技术应用于结直肠粘膜和胃癌的光镜和电镜标本表明，BD-5免疫反应物质存在于高尔基复合体中，呈小透明状，呈密集的有芯胞质囊泡，并存在于大肠粘膜的腔和侧膜糖杯中。正常细胞和腺体中的肿瘤细胞，以及分散的肿瘤细胞的外周膜中。杯状细胞胞浆中储存的粘蛋白颗粒无反应性或反应性差。在许多反应性肿瘤中观察到与大肠类型分化一致的超微结构特征。还观察到无反应性肿瘤显示出与肠分化相一致的超微结构模式，尤其是小肠类型。肠分化的迹象，包括BD-5免疫反应性，经常发生在胃癌中，而与组织学类型和疾病阶段无关。

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